MINNEAPOLIS -- Trevor Plouffe's two-run double in the bottom of the sixth inning was the difference as the Minnesota Twins defeated the Cleveland Indians 4-1 Thursday afternoon at Target Field.

The victory salvaged the final game of a three-game set for Minnesota.

With the game tied 1-1 and one out following a ground-rule double and a walk, Plouffe slapped a chopper down the third base line that reached the corner for his 33rd two-base hit of the season, giving Minnesota its second lead of the day.

Designated hitter Kennys Vargas had three hits for Minnesota, including a solo home run in the fourth inning that gave the Twins a 1-0 lead.

Cleveland DH Zach Walters tied the game in the next half inning, sending a shot over the wall in right for his seventh homer of the year and fourth since coming over to the Indians from Washington on July 31.

Right fielder Oswaldo Arcia also drove in a run for the Twins with an eighth-inning double.

Twins right-hander Phil Hughes outdueled Indians righty Corey Kluber in a battle of 13-game winners entering the day, allowing only one run on five hits over seven innings. Hughes also struck out eight to improve to 14-8, booming the first Twins pitcher to win at least 14 games since 2010.

Twins closer Glen Perkins worked a perfect ninth for his 32nd save.

Kluber (13-7) was solid, allowing only three runs on six hits over seven innings but four walks proved costly. The loss was his first since June 30 and snapped a streak of six straight decisions without one.

NOTES: Indians RHP Corey Kluber's strikeout of Danny Santana in the third inning gave him 200 strikeouts this season. Kluber is the ninth Indians pitcher to reach the 200-strikeout plateau in franchise history. ... Twins 3B Trevor Plouffe's double was his 33rd of the season, moving him into a tie for eighth in all of baseball in that category. ... Twins DH Kennys Vargas' homer was his fourth in 19 games in the majors this season. He has 17 RBIs in that span.