Greg Monroe had 26 points and 11 rebounds, Brandon Knight scored 20 points, and the Detroit Pistons beat Milwaukee 103-87 on Friday night, handing Bucks interim coach Jim Boylan his first loss.
The Pistons outscored the Bucks 33-11 in the third quarter.
Detroit led 74-60 going into the fourth quarter and squashed any hope of a Bucks comeback when Monroe scored on a hook shot, layup and dunk and Knight added a 3 as the lead grew to 83-62 with 9:57 to play.
Rodney Stuckey's 3 gave the Pistons another 21-point lead with 2:48 to go and the Bucks didn't get closer than 14 again.
Brandon Jennings and Beno Udrih had 15 points for Milwaukee.
On Monday, the Bucks and coach Scott Skiles mutually decided to part ways. Boylan, a longtime NBA assistant, who had been with Skiles in Phoenix and Chicago, took over and won his first game in charge Tuesday when the Bucks beat Phoenix 108-99.
Then, after trailing by 15, Milwaukee rallied to win 104-96 at Chicago on Wednesday.