Ryan Braun homered to highlight a five-run first inning and the Milwaukee Brewers beat the Chicago Cubs 11-5 on Friday night.
Braun had three hits and three RBIs for Milwaukee, which has won 25 of its last 31 games against Chicago.
Rickie Weeks and Martin Maldonado had three hits and two RBIs each as the Brewers scored a season-high runs in its most lopsided victory of the year.
Marco Estrada (5-2) allowed three earned runs and six hits in six innings.
Travis Wood (5-5) turned in his shortest outing of the season when he lasted only 2 2-3 innings.
He gave up 10 hits and seven earned runs for the Cubs (19-33), who have the worst record in the majors.
Chicago, shut out in its last two games at San Francisco, ended its scoreless streak at 22 innings.