Matt Holliday's two-run home run in the sixth inning stunned Wily Peralta (9-15) with the St. Louis Cardinals' first hit and rookie Shelby Miller blanked the Milwaukee Brewers into the seventh inning of a 4-2 victory Tuesday night.
Norichika Aoki of the Brewers struck out three times for the first time in the majors, the last against rookie lefty Kevin Siegrist with a runner on second to end the seventh.
Aoki entered the game as the toughest batter to fan in the majors this year, averaging one per 17.2 at-bats.
Matt Carpenter and Matt Adams added RBIs in the seventh and eighth for the NL Central leaders, who are 4-0 to begin a nine-game homestand.
After a day off, the Cardinals built on momentum from a three-game sweep of Pittsburgh.
Miller (13-9) allowed five hits with four strikeouts and two walks in 6 2-3 innings.