Juan Nicasio pitched six effective innings for his first victory in almost a year while Wilin Rosario, Michael Cuddyer and Dexter Fowler homered to lift the Colorado Rockies over the Milwaukee Brewers 7-3 on Wednesday night.
The Rockies took two of three under new manager Walt Weiss in the season-opening series at Miller Park.
Nicasio (1-0) allowed two runs and seven hits for his first win since last April 30, when he beat the Los Angeles Dodgers.
Winless in the next five starts, he sustained a season-ending knee injury on June 2.
Wily Peralta (0-1) gave up six hits and four runs over five and a third innings.
Rickie Weeks paced the Brewers offense with three hits including his first home run of the season.
The Brewers have an off day on Thursday before beginning a weekend series with the Arizona Diamondbacks at Miller Park Friday night.