NEW YORK -- Rookie catcher John Ryan Murphy hit a home run and drove in a career- high three runs while guiding five New York Yankee pitchers through a 4-3 victory over the Los Angeles Angels on Saturday at Yankee Stadium.

Murphy's first career multi-hit game began in a 1-1 game with two out in the second and the bases loaded against Angels' left-handed starter Hector Santiago (0-4), who issued the tying run on a balk.

On the sixth pitch, Murphy lined a slider into right field, scoring left fielder Brett Gardner and second baseman Brian Roberts.

When Murphy led off the fifth, he broke a 3-3 tie by driving a first-pitch fastball that hung over the outer edge of the plate into the left field seats.

As much as Murphy's production at the plate was needed, so was his ability to coax the Yankee pitching staff through after Friday's 13-1 loss.

First, Murphy guided left-hander Vidal Nuno through 4 1/3 innings. Nuno made his second start and first in place of right-hander Ivan Nova, and wound up allowing three runs and five hits.

Nuno allowed a solo home run to center fielder Mike Trout of the Angels with one out in the first. After allowing a single to designated hitter Albert Pujols, he retired the next eight batters before getting into a jam in the fourth.

The Angels tied the score with two runs in the fourth. Pujols came home from second after a failed double play attempt by the Yankees, caused by an errant throw from Roberts. A double to center field by catcher Chris Iannetta tied the score.

After allowing a two-out single to third baseman David Freese, Nuno but got out of the inning on a tremendous catch by center fielder Jacoby Ellsbury on left fielder J.B. Shuck. Shuck hit the first pitch and it began sinking fast but Ellsbury got his glove on it before hitting the ground while making a full extension.

Right-hander Dellin Betances(1-0) struck out three in two scoreless innings, although he nearly gave up solo home runs to Iannetta and Shuck on balls that barely hooked foul. He was awarded the win via official scoring rules that state the most effective pitcher can get the win when a starting pitcher does not complete five innings.

Shawn Kelley entered with the tying run on first and one out in the seventh. He walked Trout on four straight pitches but retired Pujols on a fly ball to left and struck out second baseman Howie Kendrick on a slider before allowing two hits in the eighth.

Left-hander Matt Thornton inherited first and second with two outs and ended the eighth by winning a seven-pitch encounter with pinch hitter Raul Ibanez. David Robertson stranded Trout by retiring Pujols and Kendrick for his third save.

Santiago exited with a similar line as Nuno, allowing four runs and six hits in 4 1/3 innings. After allowing Murphy's home run, he gave up consecutive singles to Ellsbury and shortstop Derek Jeter before being lifted and slamming his glove in the dugout out of frustration.

NOTES: SS Derek Jeter made his first start in a day game after a night game, although the previous instances were due to a right-handed starter facing the Yankees. … The Yankees added another reliever to their bullpen when they purchased the contract of RHP Chris Leroux from Triple-A Scranton Wilkes-Barre. They also announced that RHP Jose Campos underwent "Tommy John surgery" on Friday. … The Angels have hit 36 home runs, the most in the first month in team history, surpassing the 34 slugged in the opening month of 2000. … INF Ian Stewart made his second start at first base for the Angels.