Indiana made quick work of its first opponent in the NCAA Tournament, but Temple has established a reputation as a giant slayer.
The two teams will square off in the Big Dance for the first time since 1994 when they meet in the quarterfinals of the East Regional in Dayton, Ohio on Sunday.
The top-seeded Hoosiers never trailed against James Madison en route to an 83-62 win on Friday, shooting better than 50 percent for the fourth straight time in a NCAA Tournament game.
The ninth-seeded Owls, seeking their first Sweet 16 appearance since 2001, overcame their recent history of early exits in the NCAA Tournament with a 76-72 victory over North Carolina State.
Atlantic-10 Player of the Year Khalif Wyatt led the way with 31 points for Temple, which went 5-3 against tournament teams in the regular season, and has defeated at least one top-10 opponent in each of the last five years.
The winner of this contest will meet fourth-seeded Syracuse on Thursday in Washington, D.C.
TV: 1:45 p.m., CBS
ABOUT TEMPLE (24-9): Wyatt went 12-for-14 from the foul line Friday, giving him 200 made free throws - breaking the single-season school record held by Hal Lear (1955-56). His sixth 30-point performance of the season was the best from an Owl in the NCAA Tournament since 1991 - and was made even more remarkable considering he had injured his left thumb after snagging it in a defender's jersey early in the second half. ''He's as tough a competitor as I've had an opportunity to coach,'' Temple's Fran Dunphy said following the game. ''He wants the moment.'' Wyatt has hit at least nine free throws in six straight games, going 62-for-71 over that stretch.
ABOUT INDIANA (28-6): The Hoosiers - the highest-scoring team remaining in the tournament - exceeded 80 points for the 19th time. Freshman Yogi Ferrell finished with 16 points, eight rebounds and six assists Friday, becoming only the third Indiana player to reach those totals in a NCAA Tournament game (Keith Smart in 1987 and Tom Coverdale in 2003). " Yogi certainly got us going in a great direction with the way that he moved the ball … he was able to find some great areas to attack," coach Tom Crean said following the game. Christian Watford scored nine points Friday, giving him 1,708 points for his career and moving him into 10th place on the school's all-time scoring list.
1. Indiana is 10-1 all-time as a No. 1 seed in the NCAA Tournament.
2. Temple has nine wins as a No. 9 seed or lower, tied with Gonzaga for the most since the field expanded to 64 teams in 1985.
3. Jordan Hulls is tied with Randy Wittman and Jeff Newton for the most games played (133) by a Hoosier.
PREDICTION: Indiana 86, Temple 77