EVANSTON, Ill. -

Kain Colter ran for 161 yards and four touchdowns, and Northwestern set a school record with 704 yards of total offense in a 44-29 victory over Indiana on Saturday in both teams' Big Ten Conference opener.

Colter also finished with 131 yards receiving. Trevor Siemian threw for 308 yards, and Venric Mark ran for 138 and a touchdown on a day when the Wildcats (5-0) had to hang on after they appeared to be on their way to an easy win.

They led 27-0 lead early in the third quarter before things got interesting.

Indiana (2-2) got within 37-29 when D'Angelo Roberts scored on a 2-yard run and Kofi Hughes ran it in on a reverse for the two-point conversion. Colter helped to ice the game when he scored on a 22-yard run to make it 44-29 with just over 5 minutes left.