-- ERIC --
CERTAIN CANCER DIAGNOSES OFFER VERY LITTLE HOPE.
THERE ARE A LOT OF TREATMENTS BEING TESTED.
BUT PERHAPS SOME OF THOSE MEDICINES NEED A LITTLE
-- SUSAN --
ONLY NEWS 3'S DANNIKA LEWIS HAS THE STORY BEHIND A
HAPPENING RIGHT HERE IN MADISON.
DANNIKA LEWIS: This week.
doctors and researchers at the UW are sitting down
with a drug developer.
mapping out the latest clinical trial.
They're hoping the new medicine and a more limited
menu can help some of the most vulnerable patients.
those with metastatic breast cancer.
MARY: 3429 Just the idea that it's a chance, it's
a chance that it might work, I might as well take
1 VO TRACK
THAT'S THE MENTALITY MARY ROBERTS HAS HAD EVER SINCE
SHE WAS DIAGNOSED.
MARY: 2754, so I thought for sure I was going to
I really, really did.
2 VO TRACK
STARTING WITH THOSE SCARY MOMENTS IN 19-98.
HER TRIPLE NEGATIVE BREAST CANCER.
GOT MARY TAKING THOSE CHANCES.
ON DRUGS THAT HAVEN'T BEEN PROVEN TO IMPROVE HER CHANCES.
MARY: 3216 I am very hopeful that we will see through
these clinical trials a solution, a cure or a way
to keep this at bay,
3 VO TRACK
THE LATEST PATIENT TRIAL BEGAN HERE.
IN THE LABS OF U-W'S CARBONE CANCER CENTER.
WITH DOCTOR VINCENT CRYNS.
CRYNS: 5919 It's a, it's more than a job, let's
THERE IS A WAY TO KNOCK DOWN A CANCER CELL'S DEFENSES.
THROUGH SO-CALLED DEATH-RECEPTOR PATHWAYS.
IF THE DEATH-RECEPTORS AREN'T ACTIVATED.
THEY'RE NOT DOING MUCH TO HELP KILL OFF THE CANCER.
THE ROUTE HAS TO BE TURNED ON, IN A SENSE, FOR A CELL
TO BE VULNERABLE.
DRUGS THAT WORK THROUGH THOSE RECEPTORS ARE ONLY SOMEWHAT
EFFECTIVE ON THEIR OWN.
CRYNS: 5525 we're showing we can use this diet to
prime the tumor cells to make them respond better
to a cancer drug.
DOCTOR CRYNS HAS PROVEN, IN MICE.
THAT A VEGAN DIET TAKES AWAY A KEY NUTRIENT CELLS
USE TO PUT UP THOSE PROTECTIONS.
MAKING IT EASIER FOR THE DRUG TO GET IN AND DO ITS
CRYNS: 55__ we're in a sense stressing the tumor
cells, lowering their defenses, if you will, and now
making them more vulnerable to cell death.
O'REGAN: 4409 Any new treatment for triple negative
breast cancer is exciting,
RUTH O'REGAN, HEAD OF THE ONCOLOGY AT U-W HEALTH,
SAYS THIS TRIAL WILL BE ONE OF A KIND FOR THE DIAGNOSIS.
O'REGAN: 47__ I think we're at the tip of the iceberg
I think we're going to find that dietary modification
can be very important using other drugs as well.
CRYNS: 5557 Why not harness the power of nutrition
to make these drugs work better? 5605
MARY'S READY TO TEST MORE DRUGS.
TRY MORE DIETS.
AND TAKE MORE CHANCES.
MARY: 3039 I have two granddaughters.
and since I have the BRCA gene, I would like to see
it get knocked out before then, so.
CRYNS: 59__ we have an opportunity to create some
hope where there isn't a lot of hope.
MARY: 3017 I walk in gratefulness every day for
having the treatment that I have
DANNIKA LEWIS: Even if this clinical trial proves
a vegan diet can help take out triple negative breast
Cryns says we can't be too quick generalize the results.
Even with restrictions, he says vegan options vary.
and so do the nutrients involved.
this link could be the first discovery of its kind.
For WISC News 3.
I'm Dannika Lewis.